This is a collection of instructions for students starting work in our group, mec which is short for Metabolic Engineering CBMA.

Carrying out a MSc or PhD project is probably fundamentally different from anything that you have done before. It is important to understand why in order to make most out of your project and your time in the group.

There are a number of ways you can prepare yourself for your project in order to get up to speed.

Please read practical considerations. Verify the checklist at the end.

It is now your responsibility to:

  • understand your project.
  • think ahead on the next step of your work.
  • find and read relevant literature.
  • The wider why, how your project fits into the big picture.

The importance of initiative has been dealt with many times in the literature. It is very applicable to MSc or PhD students. For example:

“The difference between people who exercise initiative and those who don’t is literally the difference between night and day. I’m not talking about a 25 to 50 percent difference in effectiveness; I’m talking about a 5000-plus percent difference, particularly if they are smart, aware, and sensitive to others.”

Stephen R. Covey, The 7 Habits of Highly Effective People

Use your time well. Many people live out their lives doing boring repetitive tasks. We are privileged to work in a university, which is perhaps the only place where truth is sought for it own sake and where people are willing to share their knowledge. Understand that your results and the way you report them affects the body of science as a whole.

Famous physicist Richard Feynman suggested the five rules below that I reformulated a somewhat:

  • If you’re confused, ask questions.
  • If you’re stuck, seek help.
  • If you’re wrong, admit it.
  • If you make a mistake, learn from it.
  • If you learn something, teach others.

Effective meetings

Meet with your supervisor regularly by your own initiative.

  • Don’t wait for the supervisor to speak.
  • Be prepared and organized.
  • Write down a list of issues you want to discuss and prioritize.
  • Come prepared with suggestions for solutions.
  • Take notes during the meeting.
  • Ask a lot of questions.
  • Learn to disagree and disagree to learn.

If you have repeated an experiment a number of times, your supervisor will want to know which variables were changed and what the results were. If you made several similar experiments trying to troubleshoot, name your experiment like PCR-GeneX-1-feb (some name/date combinations) in order to make it easier to identify and reference.

Doing good science is hard. This is true for everyone. Your supervisor might disagree with you, but don’t not take this personally. Make sure you understand the criticism. If you disagree with your supervisor, find arguments for your point and use them. Remember, that you might have information that the supervisor does not have.

This is an important time to start building your own scientific self-confidence.

There is no shame in experiments not producing expected results, if they are well done. It’s important to present the results of your experiment honestly, even if they are negative or inconclusive. This honesty is what earns you respect as an ethical researcher within the community.

xkcd

Some useful links:

next meeting with your pi

getting the most out of supervisor meetings

English

English is the language of science. Depending on your background you may need to improve your English.

Writing good English is different from writing good Portuguese. Please take steps to improve reading, writing and understanding if you feel that you need to improve these skills.

I have collected some free resources for learning English here.

Misc

10 Things Every Molecular Biologist Should Know